Monthly Minodronate Dose Safe and Effective for Osteoporosis

Oral minodronate, when administered to osteoporosis patients as a daily 1 mg dose, has been shown to have antivertebral fracture efficacy.  Japanese researchers wanted to see if a monthly minodronate dose of 30 mg or 50 mg would have similar efficacy—they looked specifically at the changes in bone mineral density (BMD) and bone turnover markers.
Woman with a pill in her hand In this study, there were 692 patients with involutional osteoporosis. They were randomized into 3 groups:

  • Receive minodronate as a 30 mg monthly dose
  • Receive minodronate as a 50 mg monthly dose
  • Receive minodronate as a daily dose of 1 mg

The percent change from baseline to 12 months in lumbar spine BMD (LS-BMD) was the primary endpoint.  The researchers also looked at total hip BMD, bone turnover markers, parathyroid hormone (PTH) levels, and serum calcium (Ca).

In terms of change in LS-BMD, the monthly doses of mindronate (at 30 mg or 50 mg) were noninferior to the daily dose of 1 mg.  Also changes in total hip BMD were comparable.

There was a transient decrease serum Ca and an increase in PTH level in all 3 groups at slightly different magnitudes and time courses.  However, changes in bone turnover markers were comparable among the 3 groups with a similar time course.

Finally, safety profiles were also comparable.

This study shows that administering minodronate as a monthly dose of 30 mg or 50 mg has similar efficacy when compared to a daily dose of 1 mg.  This is in terms of BMD and bone turnover markers.  Monthly doses have a similar tolerability as the daily dose.

The researchers concluded that this study provides patients with a new option for minodronate.

This new regimen provides patients with a new option for taking minodronate.

Updated on: 03/08/17
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