Vertebral Augmentation and Radiotherapy of Collapse Spinal Metastatic Cancer
Purpose and Objective
The purpose of this study is to assess vertebral augmentation with radiotherapy to increase the functional status and quality of life for patients with vertebral body metastatic cancers. The study seeks to quantify the reduction of pain and changes in quality of life associated with vertebral augmentation.
This study is conducted in patients with metastatic cancer or multiple myeloma involving the spine. This study addresses the value of vertebral augmentation in combination with radiotherapy in the setting of cancer to the spine. The patient's pain, overall quality of life, and fracture development/avoidance will be compared to patients treated only with radiotherapy in the past.
Conditions: Metastatic Cancers, Multiple Myeloma, Vertebral Fracture
Intervention: Vertebroplasty, Radiotherapy
Clinical Trial Sponsor
This clinical trial is sponsored by the University of Arizona.
Recruiting Location (United States)
University of Arizona
Tucson, Arizona, United States, 85724
Contact: Jamie Holt 520-626-6800
Contact: Caroline Holcomb, MA 520 626-6800
Eligibility, Inclusion and Exclusion Criteria
- Diagnosis of metastatic disease to the vertebra or multiple myeloma
- Negative pregnancy test within 2 weeks prior to registration
- Life expectancy of >= 3 months and KPS score >= 40
- Pain scale score >=5
- Pain at involved vertebral body not adequately controlled
- Osteolysis of vertebral bodies
- Must agree to practice adequate means of birth control
- Must sign informed consent prior to study entry
- Must be able to understand the English language
- Absence of any serious cognitive or psychiatric problems potentially hampering compliance with the study and follow-up schedule.
- Spinal Cord Compression
* Additional inclusion/exclusion criteria apply. Please consult with your physician to review the complete eligibility criteria.