Vertebral Augmentation and Radiotherapy of Collapse Spinal Metastatic Cancer

Purpose and Objective

The purpose of this study is to assess vertebral augmentation with radiotherapy to increase the functional status and quality of life for patients with vertebral body metastatic cancers. The study seeks to quantify the reduction of pain and changes in quality of life associated with vertebral augmentation.
Older couple holding hands.This study is conducted in patients with metastatic cancer or multiple myeloma involving the spine. This study addresses the value of vertebral augmentation in combination with radiotherapy in the setting of cancer to the spine. The patient's pain, overall quality of life, and fracture development/avoidance will be compared to patients treated only with radiotherapy in the past.

Conditions: Metastatic Cancers, Multiple Myeloma, Vertebral Fracture
Intervention: Vertebroplasty, Radiotherapy

Clinical Trial Sponsor

This clinical trial is sponsored by the University of Arizona.

Recruiting Location (United States)

University of Arizona
Tucson, Arizona, United States, 85724
Contact: Jamie Holt    520-626-6800
Contact: Caroline Holcomb, MA    520 626-6800

Eligibility, Inclusion and Exclusion Criteria

Inclusion Criteria:

  • Diagnosis of metastatic disease to the vertebra or multiple myeloma
  • Negative pregnancy test within 2 weeks prior to registration
  • Life expectancy of >= 3 months and KPS score >= 40
  • Pain scale score >=5
  • Pain at involved vertebral body not adequately controlled
  • Osteolysis of vertebral bodies
  • Must agree to practice adequate means of birth control
  • Must sign informed consent prior to study entry
  • Must be able to understand the English language
  • Absence of any serious cognitive or psychiatric problems potentially hampering compliance with the study and follow-up schedule.

Exclusion Criteria:

  • Spinal Cord Compression

* Additional inclusion/exclusion criteria apply. Please consult with your physician to review the complete eligibility criteria.

 

Updated on: 03/16/17
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