5-Hydroxytryptophan (5-HTP)

5-Hydroxytryptophan (5-HTP) is an amino acid that is beneficial in treating depression, obesity, insomnia, fibromyalgia, migraine and headache in children.

Tryptophan (Trp) is an amino acid (balances nitrogen in adults) that the body makes from 5-HTP. In turn, Trp is converted into serotonin, which is found in platelets (maintains homeostasis) in the brain cells and the intestine. Serotonin is an important neurotransmitter and 5-HTP helps to raise levels of this chemical in the brain. Serotonin positively effects anxiety, aggression, sensation to pain, sleep, temperature, and sexual behavior.

Many anti-depressant drugs increase the level of serotonin in the brain. These drugs are used to treat mild to moderate levels of depression thereby improving mood, anxiety, and ability to sleep.

Fibromyalgia is a disorder that presents symptoms of tender joints, pain throughout the body, stiff muscles, and fatigue. Low serotonin levels may affect pain tolerance. 5-HTP raises pain tolerance, reduces anxiety, and has been shown to improve the quality of sleep.

Sources

5-HTP is plant based and is extracted from the seed of the African plant Griffonia simplicifolia. 5-HTP is found in multivitamin formulations and herbal preparations. It is available in tablets and capsules in the following doses: 25-mg, 50-mg, and 100-mg.

Guidelines and Cautions

Some sources recommend 50-mg to 100-mg of 5-HTP daily. Magnesium, niacin, and vitamin B6 assists 5-HTP's conversion to serotonin. The effects of St. John's wort may be enhanced when combined with 5-HTP.

5-HTP may cause the following side effects: heartburn, gas, a full feeling, and mild nausea.

People currently taking anti-depressant medications (monoamine oxidase inhibitors (MAOIs) or selective serotonin reuptake inhibitors (SSRIs)) should speak to a medical professional prior to taking 5-HTP.

If pregnant or nursing, diabetic, or have high blood pressure - seek the advice of a medical professional prior to taking 5-HTP.

Do not give 5-HTP to children unless directed by a medical professional.