Vitoss™ Bioactive Bone Graft Substitute:
The safety and efficacy you demand at a responsible cost

Introduction to Vitoss

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How does Vitoss™ BA work?
Vitoss with autologous bone marrow aspirate closely resembles iliac crest autograft. Iliac crest autograft has been considered the gold standard for bone grafting and provides the three components necessary for bone formation as illustrated: scaffold, cells, and signals.

Biology of Bone Remodeling

Why is ICBG the Gold Standard?

Iliac Crest Bone (ICBG) has a Calcium Phosphate (CaP) surface with an open, inter-connected structure that serves as a scaffold.

ICBG provides bone marrow rich with mesenchymal stem cells and hematopoetic stem cells that facilitate bone regeneration and neo-vascularization. In addition, ICBG provides signals that help drive bone formation

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Bone marrow is a powerful biologic driver found in iliac crest autograft.

Vitoss provides a highly porous, open-interconnected structure similar to cancellous autograft that drives the three-dimensional regeneration of bone. Vitoss has an optimized structure, porosity, bioactivity and chemistry. Minimally invasive harvest of bone marrow captures stem cells and autologous signals, which when added to Vitoss™ BA creates “synthetic autograft.”

Vitoss Bioactive Mechanism of Action
Bioactivity leads to stronger, more abundant bone growth in a shorter period of time. The bioactive component of Vitoss BA bone graft immediately begins to react once implanted, releasing ionic constituents into the environment (Si+, Na+ and Ca2+). This chemical signal induces cellular attraction to the scaffold surface and increases osteoblast proliferation and protein production.

We specifically chose Vitoss for the osteoconductive component of our graft because of its unique structure and high porosity … we have combined Vitoss with bone marrow and obtained healing results that are at least comparable to those we obtained with autograft. 1 – N.M. Wright, MD

Vitoss - Fuses efficacy, safety, and cost together.
Vitoss bone graft substitute has been evaluated in more than 18 clinical studies and in over 800 patients in spinal surgery. This data demonstrates Vitoss with autologous marrow to be a viable alternative to autograft and BMP. As the leading synthetic bone graft, Vitoss has been used successfully in over 300,000 implantations worldwide. With Vitoss, spine surgeons no longer need to compromise on the selection of a bone graft. Vitoss provides the efficacy and safety surgeons demand, at a responsible cost.

Our results show no difference in radiological and clinical outcomes between [Vitoss + BMA and rhBMP-2].  The data from this study can help physicians choose the best bone graft composition for an individual patient, taking both physiologic and economic factors into consideration.1– J.R. McConnell, MD

 

Updated on: 01/04/10
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