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Complete blood count (CBC): A drop of blood contains a number of
different cell types, including red blood cells (erythrocytes),
macrophages, neutrophils, basophils, eoisinophils, B lymphocytes,
and T lymphocytes, among others. Differences in the number or
appearance of any of these cell populations might serve as an
indication of some underlying illness. The list of possibilities
is far too long to delineate here.
Erythrocyte sedimentation rate (ESR): This measure indicates
the rate at which red blood cells settle out in a tube. An increased
rate of sedimentation can serve as sort of general indicator
of inflammation in the body.
Alanine aminotransferase (ALT):
The activity of this
enzyme is measured in blood plasma. Elevated levels of this enzyme
can be an indication of viral hepatitis and other forms of liver
disease.
Total protein: Measurement of the total protein concentration
in plasma. Elevated concentrations reflect dehydration, which
might be attributable to vomiting, diarrhea, Addison's disease,
diabetic acidosis, and other conditions.
Albumin: Albumin is the most abundant protein found in
blood plasma, representing 40 to 60% of the total protein. Reduced
levels of albumin may reflect a variety of conditions, including
primary liver disease, increased breakdown of macromolecules
resulting from tissue damage or inflammation, malabsorption syndromes,
malnutrition, and renal diseases.
Globulin: Globulins are a diverse group of proteins
in the blood, and together represent the second most common proteins
(after albumin) in the bloodstream. An elevation in the level
of serum globulin can indicate the presence of cirrhosis of the
liver.
Alkaline phosphatase (ALP): Alkaline phosphatases are
a family of enzymes that are present throughout the body. Elevated
levels of ALP are associated with liver and bile duct disorders,
and bone diseases.
Calcium: Increased levels of plasma calcium may
indicate the presence of malignant disease or hyperparathyroidism.
Less commonly, it could reflect thyrotoxicosis, vitamin D intoxication,
the use of thiazide diuretics, sarcoidosis, and other disorders.
Reduced levels of calcium may reflect vitamin D deficiency, renal
disease, hypoparathyroidism, magnesium deficiency and other disorders.
Phosphorus: Increased levels of plasma phosphate
ion may indicate imminent renal failure, hypoparathyroidism,
acromegaly, excessive phosphate intake, and vitamin D intoxication.
Sharply decreased levels of plasma phosphate may reflect vitamin
D deficiency, primary hyperparathyroidism, magnesium deficiency,
and diabetic ketoacidosis.
Glucose: Elevated blood glucose levels may be an indication
of diabetes mellitus. Lower-than-normal blood glucose levels
(hypoglycemia) can be caused in a variety of ways, often transiently,
and must be examined under specific clinical conditions before
relating this finding to any clinical disorders.
Blood urea nitrogen (BUN): Various renal diseases can lead to
an increase in the concentration of urea in blood plasma.
Electrolytes: This test measures the levels of charged
ions dissolved in the blood and urine, including sodium, potassium,
calcium, magnesium, chloride, bicarbonate, phosphate, sulfate,
and lactate. Virtually all the metabolic processes in the body
are dependent on the presence of these charged ions, the concentrations
of which are tightly controlled. Deviations from normal levels
of each of these cautions can reflect a wide variety of clinical
problems, too numerous to detail here.
Creatinine: Elevated levels of plasma creatinine may indicate
impaired renal function.
Thyroid stimulating hormone
(TSH): This is a test
of thyroid function. Higher-than-normal levels of TSH may indicate
hypothyroidism and lower-than-normal levels may suggest hyperthyroidism.
In rare instances, elevated TSH levels may be caused by pituitary
tumors.
Urinalysis: Urine may be examined for a variety of
diagnostic indicators, including amylase, bilirubin, creatinine,
sugars, g-glutamyl transferase, hemoglobin, lactate dehydrogenase,
osmolality, electrolytes, myoglobin, protein, urea, and many
more. Elevated amylase levels can indicate pancreatic disease;
increased urine bilirubin levels signal liver damage or disease;
high serum g-glutamyl transferase suggests biliary obstruction,
cholangitis, cholecyctitis and alcoholic cirrhosis; increased
lactate dehydrogenase in urine is associated with glomerulonephritis,
systemic lupus erythematosus, diabetic nephrosclerosis, and bladder
and kidney malignancies; and so forth.
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