Long Term Issues from Adverse Reaction to rhBMP-2 Cervical Surgery
I'd like to start the discussion with my question - I'd like to find professionals who have any information or can answer the question on long term affections or absorption rates and/or times on large doses of BMP in cervical surgeries, especially with self extracting drain less than 24 hours post op. Surgery May 31, 2008, tremendous autoimmune and spine issues since surgery. Fusion was not successful. Just had second PSF C3 - T1. Very good internist treating & studying me for metal toxins and metabolism.
This is a complicated and highly political topic, but I'm going to dive in. Three years ago, I had an ACDF C3-C7 with Infuse (thBMP -2) and Peek cages. A very well known and respected surgeon, used a very large dose of Infuse and my drain self extracted less than 24 hours post op. I am also highly intolerable to foreign substances inside my body. Of which the surgeon was told prior to the surgery, when questioned about the use of BMP by myself and my family. Without all of the long drawn out details - I ended up being discharged & readmitted due to critical swelling, chocking, a paralyzed epaglatis, paralyzed right vocal cord and aspiration pneumonia. I could not swallow anything, and aspirated when they tried to do a barium swallow test. A PEG feeding tube was inserted and I was sent home. The surgeon had no idea what caused the swelling post op and had never seen such a reaction from the BMP. A family member is a scientist who works in that field and quickly identified that to be the issue and e-mailed information to the doctors. Nothing helped of course, as it was too late and it was in my system.
My surgery was the last day of May 2008 and in July 2008 the Wall Street Journal came out with the article regarding the whistle blower case against Medtronics and the off label use of BMP in cervical cases. The cases they described were as if they were describing mine, and maybe I was the "feeding tube" case cited. In research I've done one of the doctor's who one of the highest paid by the Medtronics is one that shares an office with the surgeon who did my surgery. So I think he probably knew that it was risky to put that much BMP in my body, he must have, shouldn't he?? If I told him my body doesn't accept foreign material well and I have inflammation issues? But that was 3 years ago - and I am trying to live in the present.
The present - my life has never been the same. My paralysis did subside after three or four months, but other orthopedic, soft tissue and inflammation issues have plagued me ever since. I have never been out of pain since my surgery. For over a year and half I had such pain and no strength in my arms and hands I could barely use them. I've been treated like a crazy person. I have been tested for every immune disease, been diagnosed with full blown fibromyalgia, had an epicondilectomy where the tendon basically just died for no apparent reason, my spine and other joints are degenerating at such a rapid rate, at 53 years of age, I am having to live like I am in my 70s.My sciatica with bi-lateral entrapment in all five trigger points, is so bad sitting, standing walking, it is just painful. And to top it off my neck did not fuse THANK YOU INFUSE BMP so in November 2010 I had to undergo a second C3 - T1 PDF.
I have found only one research project on the absorption of rhBMP-2 and the it takes 18months to absorb into your body. My question for the professionals researches, or someone from Medtronics - is there more research? If not, this needs to be studied. Why?
Because surgeons are still pushing and using this product for cervical surgery and what happened to me can happen to them. My life as I knew it GONE! I am DISABLED! It is because of BMP - no one will convince me otherwise. It traveled down my spine, it was in my blood stream, it was in my liver, it was in my intestines - BMP was a toxin in my system and I was allergic to it. Yes, it may be one in 10,000, but I AM THE ONE! My recent surgeon tells me - I can use BMP in your posterior surgery - it won't cause a problem. I will be coping and showing him the Medtronics kit instructions which can be pulled right off of the internet which clearly states in the directions - DO NOT USE ON PATIENTS WHO HAVE HAD ADVERSE REACTIONS TO BMP!
Please if anyone has done any research on long term affects of BMP. Let me know. My internist is trying everything he can to detox my body and has been for over nine months.
2004 - 2007 - Three Shoulder Surgeries
2008 -Bi-lateral Carpal Tunnel
2008 -ACDF C3 - C7 - Critical Stenosis (Osteoarthritis)
2009 - Epicondilectomy
2011 - Posterior Fusion C3 - T1
Long recovery expected
L3 - S1 - Neurosis, Sciaticia - - - Waiting it out doing all I can for no surgery
Weekly Massage Therapy