John B. Pracyk, MD, PhD
Center for Neurosciences, Orthopedics, and Spine, P.C.
Dakota Dunes, SD
Dr. Pracyk is a neurological surgeon who completed a postgraduate fellowship in Complex Spine in the Department of Neurosurgery at the University of Iowa. He is also an experienced basic science investigator with a considerable background in cellular signal transduction as it pertains to growth and development. In addition, he has experience administering clinical outcomes research.
Dr. Pracyk concurrently received his M.D. and Ph.D. degrees through the Medical Scientist Training Program at the Duke University School of Medicine. Upon concluding his doctoral work in the Department of Pharmacology & Cancer Biology, he was awarded a Davison Fellowship to study at Cambridge University, in England. He received his General Surgery clinical training at Parkland Hospital/University of Texas Southwestern Medical Center in Dallas, Texas. He received his Neurosurgical training at Duke University and The George Washington University, in Washington D.C. In addition to his postgraduate medical education, Dr. Pracyk was competitively awarded a postdoctoral research fellowship at the National Institutes of Health in Bethesda, Maryland.
Dr. Pracyk has also served a number of academic appointments including Clinical Assistant Professor in the Department of Surgery at Texas Tech University Medical Center in Lubbock, Texas and as a Fellow/Staff Associate in the Department of Neurosurgery at The University of Iowa in Iowa City, Iowa.
Dr. Pracyk has presented at numerous clinical and research society meetings here in the U.S., and has been an invited speaker internationally at Cambridge University, Cambridge, England and The University of Nottingham, Nottingham, England.
His uniformed service experience includes serving as a Lieutenant Commander in the U.S. Public Health Service and the U.S. Public Health Service Reserve. He is also a member of the American Medical Association, the Congress of Neurological Surgeons (CNS), American Association of Neurological Surgeons (AANS) and has been elected into the Sigma Xi Research Society.
1. Pracyk, J.B., Eylers, J.P., Seidler, F.J. and Slotkin, T.A. Effects of hyperthyroidism on ODC activity and its reactivity to Ã-adrenegic stimulation in neonatal heart. Neurotoxicology, 9: 686, 1988.
2. Pracyk, J.B., and Massey, J.M. Moyamoya disease associated with polycystic kidney disease and eosinophilic granuloma. Stroke, 20: 1092-94, 1989.
3. Diamond, D. (Pracyk, J.B., contributor/published interview). How many chips off the old doc are you raising? Medical Economics, October 16, 1989.
4. Pracyk, J.B., Lappi, S.E. and Slotkin, T.A. Role of thyroid stimulating hormone in the development of Ã-adrenegic control of ornithine decarboxylase in the rat heart and kidney. Journal of Pharmacology and Experimental Therapeutics, 256: 757-766, 1991.
5. Pracyk, J.B., and Slotkin, T.A. Thyroid hormone differentially regulates development of Ã-adrenergic receptors, adenylate cyclase and orinthine decarboxylase in rat heart and kidney. Journal of Developmental Physiology, 16: 251-261, 1991.
6. Pracyk, J.B., and Slotkin T.A. The permissive role of endogenous thyroid hormone in the developmental regulation of Ã-adrenergic receptors and adenylate cyclase in rat heart and kidney. Journal of Pharmacology and Experimental Therapeutics, 261: 951-958, 1992.
7. Pracyk, J.B., Seidler, F.J., McCook, E.C. and Slotkin, T.A. Pituitary-thyroid axis reactivity to hyper-hypothyroidism in the perinatal period: Otogeny of regulation and longterm programming of responses. Journal of Developmental Physiology, 18: 105-109, 1992.
8. Pracyk, J.B., Pollard, S.G., and Calne, R.Y. The Development of Spontaneous coloumbilical fistula. Postgraduate Medical Journal, 69: 750-751, 1993.
9. Pracyk, J.B., Stolp, B., Fife, C.E., Gray, L., and Piantadosi, C.A. Brain computerized tomography after hyperbaric oxygen therapy in carbon monoxide toxicity. Undersea and Hyperbaric Medicine, 22: 1-7, 1995.
10. Pracyk, J.B., Simonson, S., Young, S.L., Ghio, A.J., Roggli, V.L., and Piantadosi, C.A. Composition of lung lavage in pulmonary alveolar microlithiasis. Respiration, 63: 254-260, 1996.
11. Pracyk, J.B., Heglund, D.B. and Tanaka, K. Effect of a dominant negative Ras on myocardial hypertrophy by using adenoviral-mediated gene transfer. Surgery, 122: 404-411, 1997.
12. Moore, K.A., Sethi, R., Doanes, A.M., Johnson, T.M., Pracyk, J.B., Kirby, M., Irani, K., Goldscmidt-Clermont, P.J., and Finkel, T. Rac 1 is required for cell proliferation and G2/M pregression. Biochemical Journal, 326: 17-20, 1997.
13. Pracyk, J.B., Wall, T.C., Longbaugh, J.P., Tice, J.P., Hochrein, F.D., Green, J., Cox, G., Lee, K., Stack, R.S., Tcheng, J.E. A randomized trial of vascular hemostasis techniques to reduce femoral vascular complications after coronary intervention. American Journal of Cardiology, 81: 970-976, 1998.
14. Kim, S.S., Takeda, K., Sethi, R., Pracyk, J.B., Tanaka, K., Yu, Z.X., Ferrans, V.J., Bruder, J.T., Kovedsdi, Kirby, M. Irani, K., Goldsmidt-Clermont, P., and Finkel, T. Protection from reoxygenation injury by inhibition of Rac 1. Journal of Clinical Investigation, 101: 1821-1826, 1998.
15. Pracyk, J.B., Takeda, K., Heglund, D.D., Sethi, R., Kim, K.S., Blazina, D.R., Lee, L., Bruder, J.T., Kovedsdi, I., Goldscmidt-Clermont, P.J., Irani, K., and Finkel, T. A requirment for the rac1 GTPase in the signal transduction pathway leading to cardiac myocyte hypertrophy. Journal of Clinical Investigation, 102: 929-937, 1998.
16. Tanaka, K., Pracyk, J.B., Takeda, K., Yu, Z.X., Ferrans, V.J., Deshpande, S.S., Ozaki, M., Hwang, P.M., Lowenstein, C.J., Irani, K., and Finkel, T. Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism. Journal of Biological Chemistry, 40: 25922-25928, 1999.
17. Pracyk, J.B., Drennan, S., Tcheng, J.E. Hemostasis of the femoral vasculature: Shouldn't we have an answer by now? American Heart Journal, 138: 1014-5, 1999.
18. Heimberger A. B., Learn C. A., Archer G. E., McLendon R. E., Chewning T. A., Tuck F. L., Pracyk J. B., Friedman A. H., Friedman H. S., Bigner D. D., Sampson J. H. Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (Iressa). Clin Cancer Res, November 8(11): 3496-3502, 2002.
19. Pracyk, J.B., Traynelis, V.C., Relieving Back and Neck Pain in Those Hard to Reach Places, SpineUniverse.Com, Online Publication, March 8, 2005.
20. Pracyk, J.B., Traynelis, V.C. Treatment of the Painful Motion Segment: Cervical Arthroplasty, Spine, 30(16S) Supplement: S23-32, August 15, 2005.
21. Pracyk, J.B. Traynelis, V.C. Disorders of the spinal cord, in Spivak JM, Connolly PJ (eds):Orthopedic Knowledge Update: Spine, 3rd ed. American Academy of Orthopaedic Surgeons, Rosemont, Illinois, 2006, pp 251-258.
22. Pracyk, J.B., Traynelis, V.C. Acute intervention for cervical, thoracic and lumbar spinal disc disease, in Loftus C., (ed): Neurosurgical Emergencies, Thieme Publishers, Inc., 2008, pp 197-208.
1. Pracyk, J.B., Lappi, S.E. and Slotkin, T.A. Thyroid hormones program development of Ã-adrenergic signal transduction in the neonatal rat heart. The FASEB Journal, 3: 3534, 1990.
2. Pracyk, J.B., and Slotkin, T.A. Abnormal thyroid status causes aberrant development of the Ã-adrenergic receptor transduction mechanism in the rat heart. The Toxicologist, 12: 1126, 1991.
3. Pracyk, J.B., and Slotkin, T.A. Differential ontogenetic regulation of Ã-adrenergic transduction mechanisms by thyroid hormone. The FASEB Journal, 5: 5020(A13236), 1991.
4. Pracyk, J. B., and Slotkin T.A. Thyroid hormone deficiency disrupts development of Ã-adrenergic signal transduction in the neonatal rat heart. Neuroscience Abstracts, 17: 2 (530.2) 1991.
5. Pracyk, J.B., and Slotkin, T.A. Thyroid hormone deficiency arrests development of Ã-adrenergic receptor transduction mechanisms in the neonatal heart. The Toxicologist, 12: 1509, 1992.
6. Pracyk, J.B., Stolp, B., Fife, C.E., Gray, L., and Piantadosi, C.A. Brain computerized tomography after hyperbaric oxygen therapy in carbon monoxide toxicity. Journal of Emergency Medicine, 14: 2, 276-277, 1996.
7. Pracyk, J.B., Wall, T.C., Longabaugh, J.P., Tice, F.D., Hochrien, J., Green, C., Cox, G., Lee, K., Stack, R.S., and Tcheng, J.E. Femoral vascular complications following coronary intervention: Is mechanical clamp hemostasis better than hand-pressure? Circulation, 94: 377, 1996.
8. Pracyk, J.B., Tanaka, K., Irani, K., and Finkel, T. Rac1 dependent pathways regulate cardiac cell morphology and hypertrophy in the neonatal rat heart. Proceedings of Society of University Surgeons, 58: 58, 1997.
9. Gorecki, J., Rubin, L., Bulsara, K., Pracyk, J.B., and Chambers, J. Prospective randomized controlled clinical trial comparing intrathecal narcotic analgesia to standard medical management in benign pain. Proceedings of the Congress of Neurological Surgeons, 48: 312, 1998.
10. Pracyk, J.B., Villavicencio, A.T., Hussain, A., and Gorecki, J. Intraoperative somatosensory evoked potentials for nucleus caudalis DREZ lesioning, technical modifications and results. Proceedings of the Congress of Neurological Surgeons, 49: 109, 1999.
11. Pracyk, J.B., Villavicencio, A.T., Rubin, L.L., Dimitriov, D., Bulsara, K., Chamber, J., and Gorecki, J. A prospective, randomized controlled clinical trial of intrathecal narcotic analgesia for chronic pain of non-malignant origin. Proceedings of the Congress of Neurological Surgeons, 49: 418, 1999.
12. Sampson, J.H., Bigner, D. D., Learn, C., Friedman, A. H., Friedman, H. S., Pracyk, J.B., Riggins, G. J., Archer, G. E., McLendon, R. E., Heimberger, A. B. Brain tumor growth in mice inhibited by blockade of epidermal growth factor receptor but not epidermal growth factor vIII with a selective epidermal growth factor tyrosine kinase inhibitor. Proceeding of the American Association of Neurological Surgeons, 118: 825 (2003).
13. Lindley, T.E., Guillaume, D.J., Hitchon, P.W., Traynelis, V.C., Pracyk, J.B. Laminectomy alone verus laminectomy plus instrumentation for the management of lumbar stenosis. Proceeding of the American Association of Neurological Surgeons, 05-A-773-AANS (2004).
1. Pracyk, J.B. Proceedings from the Science, Technology, Ethics and Policy Symposium. (STEP 82) Duke University Symposium Committee, (Pracyk, J.B. ed).
2. Pracyk, J.B. The ontogeny of feeding: Hindbrain mediated ingestion in decerebrate rats. Undergraduate honors thesis, Department of Zoology, Duke University, April 1985.
3. Pracyk, J.B. The role of thyroid hormone in the ontogenic regulation of Ã-adrenergic signal transduction. Ph.D. Dissertation, Duke University, 1991.
University of Buffalo, Interventional Neuroradiology Peer Review Conference, Jackson Hole, Wyoming, July 31 -August 4, 2001.
International Invitational Presentations
University of Cambridge, The Clinical School, Medicine and Surgery Seminar Series, Cambridge, England, July 14, 1997.
University of Nottingham, Society of University of Surgeons, Tripartite Meeting, Nottingham, England, July 9-11, 1997.
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