Timothy C. Ryken, MD's portrait
Timothy C. Ryken, MD
Associate Professor, Department of Neurosurgery
University of Iowa College of Medicine
Iowa City, IA

About Timothy C. Ryken, MD

Timothy Ryken, MD is an Iowa native. He attended Iowa State University majoring in Biochemistry where he received highest honors and was elected to Phi Beta Kappa. He completed medical school at the University of Iowa in 1984 with election to AOA. He worked as a neurochemistry research assistant throughout that time and following medical school entered neurosurgical training completing residency at the University of Iowa in 1995. He received one of the highest honors available to neurosurgical residents being named the American Association of Neurological Surgeon VanWagenen Fellow for 1995 and was awarded a year of study at the University of Cambridge where he developed techniques for genetic modification of central nervous system cells.

Dr. Ryken joined the faculty at the State University of New York, Department of Neurosurgery in Syracuse in 1996. He was named the first recipient of Robert and Molly King Endowed Chair in Neuroscience for research in brain tumor treatments. He subsequently returned to the University of Iowa, Division of Neurosurgery as Assistant Professor in 1998 to further develop therapies for central nervous system neoplasia.

Since returning to the University of Iowa his focus has been on development of a multi-disciplinary clinic for brain tumor treatment, the initiation of the molecular neurosurgical laboratory to study the genetic alterations in glioma as well as developmental neuro-biology and pursued an interest in computer assisted image guided surgery and radiosurgery.

In addition to his interest in central nervous system tumors, he has been extensively involved in spinal surgery. He received the Mayfield award of the Joint Section on Spine and Disorder of the Peripheral Nerves in 1994 and has numerous publications in spinal biomechanical studies. He has served as Scientific Program Chair, and Annual Meeting Chair of the Joint Spine Section Meeting. He co-authored the widely quoted AANS/CNS sponsored publication on Guideline for the Management of Acute Spine and Spinal Cord Injuries. He is also involved nationally with the AANS/CNS Joint Section on Tumors, the Society for Neuro-oncology, the Society for Neuroscience, and the American Association of Cancer Research. He is currently a member of the AANS/CNS Joint Section on Tumors task force on development for Guideline in the Initial Management of Malignant Glioma.

He has been supportive in university committees as well, serving on the Faculty Practice Plan Management Committee, the Utilization Review Committee, the Department of Surgery Computer and Clinics Committees, the College of Medicine Research Committee, the Genetic Vector Advisory Committee and is a member of the Institutional Review Board. He provides faculty support for the patient-oriented Brain Tumor Support Group conducted here at the University of Iowa.

Publications

Peer Reviewed Papers

 

1. Lim R, Hicklin DJ, Ryken TC, Han X, Kang-Nian L, Miller JF, Baggenstoss BA: Suppression of glioma growth in vitro and in vivo by glia maturation factor. Cancer Research 46:5241-5247, 1986.

2. Lim R, Hicklin DJ, Ryken TC, Miller JF: Endogenous immunoreactive glia maturation factor-like molecule in astrocytes and glioma cells. Developmental Brain Research 33:49-57, 1987.

3. Ryken TC, Turner JW, Hicklin DJ, Miller JF, Baggenstoss BA, Lim R: Induction of cytoskeletal alterations in C6 glioma by glia maturation factor. International Journal of Developmental Neuroscience 5(3):215-225, 1987.

4. Strawn K, Ryken TC, Black D: Extreme haircutting and psychosis. American Journal of Psychiatry 144(8):1102, 1987 (letter).

5. Lim R, Hicklin DJ, Ryken TC, Miller JF, Bosch EP: Endogenous immunoreactive glia maturation factor-like molecule I cultured rat Schwann cells. Brain Research 468(2):277-284, 1988.

6. Ryken TC, Merrell AN: Haloperidol-induced neuroleptic malignant syndrome in a 67 year old woman with parkinsonism. Western Journal of Medicine 151:326-328, 1989.

7. Bright DA, Gaupp FB, Becker LJ, Schiffert MG, Ryken TC: Amoxicillin overdose with gross hematuria. Western Journal of Medicine 150:698-699, 1989.

8. Ryken TC, Henderson ST, Merrell AN: Stigmatophilia. Medical Aspects of Human Sexuality, January, 50-51, 1990.

9. Ryken TC, Turner JW, Haynes T: Bilateral testicular torsion in a preterm neonate. Journal of Urology 143:102-103, 1990.

10. Ryken TC, Merrell AN: Haircutting and psychosis revisited. Journal of Clinical Psychiatry 51(2):83, 1990 (letter).

11. Ryken TC, Traynelis VC, Lim R: Interaction of acidic fibroblast growth factor and transforming growth factor-beta in normal and transformed glia in vitro. Journal of Neurosurgery 76(5):850-855, 1992.

12. Menezes AH, Ryken TC: Craniovertebral abnormalities in Down's syndrome. Pediatric Neurosurgery 18(1):24-33, 1992.

13. Ryken TC, Traynelis VC: Interaction of acidic fibroblast growth factor and transforming growth factor-beta in cultured endothelium. Surgical Forum 43:535-537, 1992.

14. Ryken TC, Menezes AH: Cervicomedullary compression by separate atlantal lateral mass. Pediatric Neurosurgery 19:165-168, 1993.

15. Traynelis VC, Ryken TC, Rodnitzky RL, Menezes AH: Botulinum toxin in cervical immobilization. Journal of Neurosurgery 77(5):808-809, 1992.

16. Ryken TC, Hitchon PW, Roach RM, Traynelis VC: Intratentorial stereotactic biopsy: a review of eleven cases. Stereotactic and Functional Neurosurgery 59:111-114, 1992.

17. Ryken TC, Traynelis VC, Sandra A: Investigation of lipid metabolism in normal glia using a fluorescent ceramide probe. Surgical Forum 44:562-564, 1993.

18. Gerdes JS, Ryken TC, Traynelis VC: Morphological and ultrastructural analysis of C6 glioma in vitro. Surgical Forum 44:560-562, 1993.

19. Ryken TC, Menezes AH: Non-rheumatoid cranial settling. Spine 18(16):2525-2527, 1993.

20. Menezes AH, Ryken TC: Craniovertebral abnormalities in Down's syndrome (comment). Pediatric Neurosurgery 19(4):224, 1993.

21. Ryken TC, Menezes AH: Cervicomedullary compression in achondroplasia. Journal of Neurosurgery 81:43-48, 1994.

22. Ryken TC, Robinson R, VanGilder JC: Familial occurrence in subependymoma. Journal of Neurosurgery 80:1108-1111, 1994.

23. Ryken TC, Robinson R, VanGilder JC: Subependymoma in siblings. Journal of Neurosurgery, 81(6):961-962, 1994 (letter).

24. Ryken TC, Sawin PD, Runge TC, Traynelis VC: 8-isoprostane production in normal and transformed glia. Surgical Forum 45:577-579, 1994.

25. Ryken TC, Hitchon PW, VanGilder JC, Wen BC, Jani S: Interstitial brachytherapy versus cytoreductive surgery in recurrent malignant glioma. Stereotactic and Functional Neurosurgery 63:241-245, 1994.

26. Menezes AH, Ryken TC: Craniocervical intradural neurenteric cysts. Pediatric Neurosurgery 22:88-95, 1995.

27. Traynelis VC, Ryken TC, Cornelius AS: Cytotoxicity of cis-parinaric acid in cultured malignant gliomas. Neurosurgery 37(3):484-489, 1995.

28. Ryken TC, Clausen JD, Traynelis VC, Goal VJ: Biomechanical analysis of bone mineral density, insertion technique, screw torque and holding strength of anterior cervical plate screws. Journal of Neurosurgery 83:325-329, 1995.

29. Ryken TC, Goel VJ, Traynelis VC, Clausen JD: Assessment of unicortical and bicortical fixation in a quasi-static cadaveric model: role of bone mineral density, screw torque and holding index. Spine 20:1861-1867, 1995.

30. Pfeiffer M, Gilbertson LG, Goel VK, Griss P, Keller JC, Ryken TC, Hoffman HE: Effect of specimen fixation method on pullout tests of pedicle screws. Spine 21(9):1037-1044, 1996.

31. Clausen JD, Ryken TC, Traynelis VC, Sawin PD, Dexter FD, Goel VJ: Biomechanical comparison of Caspar and Cervical Spine Locking Plate Systems in a cadaveric model. Journal of Neurosurgery 84:1039-1045, 1996.

32. Lovick DS, Ryken TC, Traynelis VC, Dexter F: Assessment of primary and salvage lateral mass screw insertion torque in a cadaveric model. Journal of Spinal Disorders 10(5):431-435, 1997.

33. Svendsen CN, Skepper J, Rosser AE, Terborg MG, Tyres P, Ryken TC: Restricted growth potential of rat neural precursors as compared to mouse. Developmental Brain Research 99:253-258, 1997.

34. Soults C, Canute G, Ryken TC: Evidence based review of re-operation in the management of malignant glioma. Neurosurgical Focus 4(6):Article 11, 1998.

35. Goel VK, Clausen JD, Sawin PD, Ryken TC, Traynelis VC: Investigation of stabilizing potential of two anterior cervical spine plating systems incorporating unicortical locking screw designs. Neuro-Orthopedics, 25:67-74, 1999.

36. Taggard DA, Menezes AH, Ryken TC: Instability of the craniovertebral junction and treatment outcomes in patients with Down's syndrome. Neurosurgical Focus 6(6):Article 3, 1999.

37. Ryken TC, Julien T, Frankel B, Canute G, Haller J, Rosenbaum A: Image-injected frameless stereotactic approach to the anterior craniovertebral junction. Neurosurgical Focus 6(6):Article 9, 1999.

38. Ryken TC, Menezes AH: Inflammatory bowel disease and the craniocervical junction. Neurosurgical Focus 6(6):Article 10, 1999.

39. Frankel B, Longo SL, Ryken TC: Human astrocytomas co-expressing fas and fas ligand also produce tgf beta-2 and bcl-2. Journal of NeuroOncology 44:363-366, 1999.

40. Frankel B, Longo SL, Ryken TC: Co-expression of fas and fas ligand in human non-astrocytic glial tumors. Acta Neuropatholgica 98(4):205-212, 1999.

41. Taggard DA, Menezes AH, Ryken TC: Treatment of Down's syndrome-associated craniovertebral junction abnormalities. Journal of Neurosurgery 93 (2 Suppl): 205-213, 2000.

42. Ryken TC, Frankel B, Longo SL, Sibenaller Z: Interaction of fas and fas ligand in a rat 36B10 glioma model. Neurosurgical Focus 8, 2000.

43. Julien T, Frankel B, Traynelis VC, Ryken TC: Evidence-based analysis of odontoid fracture management. Neurosurgical Focus 8, 2000.

44. Julien T, Frankel B, Longo SL, Kyle M, Gibson S, Shillitoe EM, Ryken TC: Anti-sense mediated inhibition of the bcl-2 gene induces apoptosis in human malignant glioma. Surgical Neurology 53(4):360-368, 2000.

45. Frankel B, Longo SL, Kyle M, Canute GW, Ryken TC: Tumor Fas (APO-1/CD95) upregulation results in increased apoptosis and survival for rats with intracranial malignant glioma. Neurosurgery 49(1): 168-175, 2001.

46. Haller JW, Ryken TC, Gallagher TA, Vannier MW: Infrastructure for image guided surgery. Academic Radiology 8(9): 888-97, 2001, Sept.

47. Ryken TC, Meeks SL, Buatti JM, Bouchet LG, Bova FJ, Traynelis V. Ultrasonic guidance for spinal extracranial radiosurgery: technique and application for metastatic spinal lesions. Neurosurgical Focus 11(6) 8, 2001.

48. Ryken TC, Meeks S, Pennington EC, Hitchon P, Traynelis V, Mayr NA, Bova FJ, Friedman WA, Buatti JM :Initial clinical experience with frameless stereotactic radiosurgery. International Journal of Radiation Oncology and Biological Physics 51(4) 1152-8, 2001, November 15.

49. Meeks SL, Ryken TC, Pennington EC, Bova FJ, Friedman WA, Buatti JM: Testing and initial experience with an image-guided system for frameless stereotactic radiosurgery. Radiosurgery 4:251-261, 2002.

50. Buatti JM, Meeks SL, Ryken TC, Carlise TL. Low grade gliomas:answering one question in a myriad of new questions. J Clin Oncol 20(9) 2223-2224, 2002.

51. Meeks SL, Buatti JM, Bouchet LG, Ryken TC, Traynelis V, Pennington EC, Bova FJ, Friedman WA. Ultrasound guided extracranial radiosurgery; technique and application. Int J Radiati Oncol Biol Phys 55(4):1092-1101, 2003.

52. Paulino AC, Wen BC, Mayr NA, Tannous R, Loew TW, Goldman FD, Meeks SL, Ryken TC, Buatt JM. Protracted radiotherapy treatment duration in medulloblastoma. Am J Clin Oncol 26)1):55-9, 2003.

53. Haller JW, Ryken TC, Vannier MW. Image Guided Surgery of the Spine. Journal of Minimally Invasive Spinal Tech (1) 87-92, 2001.

54. Ryken TC, Sanford M, Traynelis V, Haller J, Bouchet L, Bova F, Pennington E, Buatti J. Ultrasonographic guidance for spinal extracranial radiosurgery: technique and application for metastatic spinal lesions. Neurosurg. Focus 11(6) Article 8, December, 2001.

55. Marinho A, Barua M, Haller J, Ryken TC. Enhanced Anatomic Visualization with Ultrasound-Assisted Intracranial Image-Guidance in Neurosurgery. Technology in Cancer Research & Treatment 1(3) 181-185, June 2002.

56. Costello F, Kardon R, Wall M, Kirby P, Ryken TC, Lee A. Papilledema as the Presenting Manifestation of Spinal Schwannoma. J Neuroophthalmology 22(3):199-203, 2002.

57. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Cervical Spine Immobilization before Admission to the Hospital. Neurosurgery 50 (3)(Supplement) pp S7-S17, 2002.

58. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Transportation of Patients with Acute Traumatic Cervical Spine Injuries. Neurosurgery 50 (3) (Supplement) pp S18-S20, 2002.

59. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Clinical Assessment after Acute Cervical Spinal Cord Injury. Neurosurgery 50 (3) (Supplement) pp S21-S29, 2002.

60. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Radiographic Assessment of the Cervical Spine in Asymptomatic Trauma Patients. Neurosurgery 50 (3) (Supplement) ppS30-S35, 2002.

61. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Radiographic Assessment of the Cervical Spine in Symptomatic Trauma Patients. Neurosurgery 50 (3) (Supplement) ppS36-S43, 2002.

62. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Initial Closed Reduction of Cervical Spine Fracture-Dislocation Injuries. Neurosurgery 50 (3) (Supplement) pp S44-S50, 2002.

63. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Management of Acute Spinal Cord Injuries in an Intensive Care Unit or Other Monitored Setting. Neurosurgery 50 (3) (Supplement) pp S51-S57, 2002.

64. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Blood Pressure Management after Acute Spinal Cord Injury. Neurosurgery 50 (3) (Supplement) pp. S58-S62, 2002.

65. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Pharmacological Therapy after Acute Cervical Spinal Cord Injury. Neurosurgery 50 (3) (Supplement) pp. S63-S72, 2002.

66. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Deep Venous Thrombosis and Thromboembolism in Patients with Cervical Spinal Cord Injuries. Neurosurgery 50 (3) (Supplement) pp S73-S80, 2002.

67. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Nutritional Support after Spinal Cord Injury. Neurosurgery 50 (3) (Supplement) pp S81-S84, 2002.

68. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Management of Pediatric Cervical Spine and Spinal Cord Injuries. Neurosurgery 50 (3) (Supplement) pp S85-S99, 2002.

69. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Spinal Cord Injury without Radiographic Abnormality. Neurosurgery 50 (3) (Supplement) ppS100-S104, 2002.

70. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Diagnosis and Management of Traumatic Atlanto-occipital Dislocation Injuries. Neurosurgery 50 (3) (Supplement) pp. S105-S113, 2002.

71. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Occipital Condyle Fractures. Neurosurgery 50 (3) (Supplement) pp S114-S119, 2002.

72. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Isolated Fractures of the Atlas in Adults. Neurosurgery 50 (3) (Supplement) pp S120-S124, 2002.

73. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Isolated Fractures of the Axis in Adults. Neurosurgery 50 (3) (Supplement) pp. S125-S139, 2002.

74. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Management of Combination Fractures of the Atlas and Axis in Adults. Neurosurgery 50 (3) (Supplement) pp. S140-S147, 2002.

75. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Os Odontoideum. Neurosurgery 50 (3) (Supplement) pp. S148-S155, 2002.

76. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Treatment of Subaxial Cervical Spinal Injuries. Neurosurgery 50 (3) (Supplement) pp S156-S165, 2002.

77. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Management of Acute Central Cervical Spine Cord Injuries. Neurosurgery 50 (3) (Supplement) pp. S166-S172, 2002.

78. Hadley MN, Walters BC, Grabb PA, Oyesiku NM, Przybylski GJ, Resnick DK, Ryken TC. Management of Vertebral Artery Injuries after nonpenetrating Cervical Trauma. Neurosurgery 50 (3) (Supplement) pp. S173-S179, 2002.

79. Ryken TC, Haller JW. Modication of Reference Array Attachment for Image Guided Neurosurgery: Direction Cranial Fixation. Technology In Cancer Research & Treatment 1(5) 401-404, 2002.

80. Resnick DK, Malone DG, Ryken TC. Guidelines for the use of discography for the diagnosis of painful degenerative lumbar disc disease. Neurosurg Focus 13(2): 1-9, 2002.

81. Eichholz KM, Ryken TC. Complications of revision spinal surgery. Neurosurg Focus 15(3):1-10.

82. Ryken TC, Eichholz KM, Gertzen PC, Welch WC, Gokaslan ZL, Resnick DK. Evidence-based review of the surgical management of vertebral column metastatic disease. Neurosurg Focus 15(5):1-10, 2003.

83. Ray W, Ryken TC. Anatomic Visualization with Ultrasound-Assisted Intracranial Image-Guidance in Neurosurgery: A Report of 30 Patients. J of the American College of Surgeons. On-line at ScienceDirect (http://authors.elsevier.com/sd/article/S1072751504003862)

Books and Book Chapters

1. Ryken TC, Loftus CM: Surgical management of anterior communicating artery aneurysms, in Wilkins R (ed.):Neurosurgical Operative Atlas, Williams and Wilkins, Baltimore, 1992, Vol. 2(4), pp. 273-281.

2. Ryken TC, Loftus CM: Surgical Management of Cerebral Abscess, in Wilkins R (ed):Neurosurgical Operative Atlas, William and Wilkins, Baltimore, 1993, Vol. 3(6), pp. 449-457.

3. Ryken TC, Menezes AH: Intraoperative electrical and manometric monitoring techniques in lumbosacral surgery, in Loftus CM, Traynelis VC (eds):Intraoperative Monitoring Techniques in Neurosurgery, McGraw-Hill, New York, 1994, pp. 257-268.

4. Menezes AH, Ryken TC: Craniovertebral junction abnormalities in the pediatric spine, in Weinstein SL (ed):Pediatric Spine: Principles and Practice, Raven Press, New York, 1994, Vol. 1, 00. pp. 307-321.

5. Ryken TC, Traynelis VC: Acute bony decompression of the optic and facial nerves, in Loftus CM (ed):Neurosurgical Emergencies (AANS Neurosurgical Topics), Williams and Wilkins, Baltimore, 1994, Vol. 1, 00. pp. 195-216.

6. Menezes AH, Ryken TC: Instrumentation of the craniocervical region, in Benzel EC (ed):Spinal Instrumentation (AANS Neurosurgical Topics), Williams and Wilkins, Baltimore, 1994, Vol. 2, pp. 47-62.

7. Traynelis VC, Ryken TC: Anterior bicortical plate stabilization of the cervical spine, in Hitchon PW, Rengachery S, Traynelis VC (eds):Spinal Fusion and Stabilization, Thieme Medical Publishers, New York, 1995, pp. 170-175.

8. Goel VJ, Clausen JD, Ryken TC, Traynelis VC: Biomechanics of the cervical spine, in Hitchon PW, Rengachery S, Traynelis VC (eds):Spinal Fusion and Stabilization, Thieme Medical Publishers, New York, 1995, pp. 38-50.

9. Menezes AH, Ryken TC: Abnormalities of the craniocervical junction, in Cheek WR (ed):Pediatric Neurosurgery, third edition, WB Saunders, Philadelphia, 1994, pp. 139-158.

10. Ryken TC, Menezes AH: Abnormalities of the craniovertebral junction in Down's syndrome, in Principles of Spinal Surgery, Menezes AH, Sonntag VK (eds): McGraw-Hill, New York, Volume 1, Chapter 23, pp. 395-409, 1996.

11. Ryken TC: Pseudotumor cerebri, hydrocephalus and ventriculoperitoneal shunts in pregnancy, in Loftus CM (ed):Neurosurgical Complication of Pregnancy (AANS Neurosurgical Topics), Williams and Wilkins, Baltimore, 1995, pp. 165-176.

12. Ryken TC, Menezes AH: Cervicomedullary compression in achondroplasia, in Ross JS (ed):The Year Book of Neuroradiology, Mosby, Chicago, in press.

13. Ryken TC, Menezes AH: Cervicomedullary compression in achondroplasia, in Young L (ed):The Year Book of Diagnostic Radiology, Mosby, Chicago, in press.

14. Watts CW, Ryken TC: Intraspinal hemorrhage from idiopathic or structural causes, in Grossman R, Loftus C (eds):Principles of Neurosurgery, Lippincott-Raven, Philadelphia, 1999, pp. 627-638.

15. Traynelis VC, Ryken TC: Evaluation, management and surgical repair of cervical spinal column trauma, in Grossman R, Loftus C (eds):Principles of Neurosurgery, Lippincott-Raven, Philadelphia, 1999, pp. 183-196.

16. Soults CB, Ryken TC: Atypical bacterial infections: actinomycosis and nocardiosis, in Osenbach R, Zeidman S (eds):Infections of the Central Nervous System: Diagnosis and Management, Lippincott-Raven, Philadelphia, in press.

17. Menezes AH, Ryken TC, Brockmeyer DL: Abnormalities of the craniocervical junction, in Pediatric Neurosurgery: Surgery of the Developing Nervous System, 4th Edition, McLone DG (ed): WB Saunders Company, Orlando, Florida, Chapter 33, pp 400-422, 2000.

18. Menezes AH, Ryken TC: Craniovertebral junction abnormalities in the pediatric spine in The Pediatric Spine: Principles and Practice, Weinstein SL (ed): Lippincott Williams & Wilkins, Philadelphia, Chapter 11, pp 219-237, 2001.

19. Ferrara L, Ryken TC: Screw pullout testing, in An H (ed):Biomechanics of Bone Testing, Springer-Verlag, in press (2003).

20. Ferrar L, Ryken TC: Osteoporosis in interbody Fusion, in An H (ed):Biomechanics of Osteoporotic Bone, Springer-Verlag, in press (2003).

21. Ryken TC, Buatti JM, Carlisle T: Central Nervous System Colon Cancer Metastases in Principles of NeuroOncology (ed Sawaya and Berger), Lippincott, in press (2003).

22. Ryken TC: Management of Malignant Glioma, in Evidence Based Neurosurgery, Walters and Haines (eds), Thieme, in press (2003).

23. Buatti JM, Meeks SL, Ryken TC. The Role of Fractionated Conformal Radiotherapy in the Treatment of Pituitary Tumors. In Cancer of the Central Nervous System, 2nd Edition. Peter McL. Black and Jay S. Loeffler (eds.) Lipincott Williams and Wilkins, Philadelphia, PA, In Press 2003.

24. Anderson S, Ryken TC: Intracranial Tumors. Handbook of Clinical Neuropsychology, Morgan and Ricker (eds), Swets & Zeitlinger, in press (2004).

25. Ryken TC, Carlisle T, Buatti J. Intracerebral Metastatic Colon Carcinoma. Textbook of Neuro-Oncology. Mitchel S. Berger and Michael D Prados (eds), Elseview Saunders, Chapter 58 pp 443-450, 2005.

Electronic Publications

2000-2001
America'sDoctor.com. Monthly electronic community discussion on "Brain and Spinal Tumors". Published in the University of Iowa Virtual Hospital.

1999-2001
INFORMED Technical Advisor, www.informed.com.

2001-present
Spinal surgery advisory panel. Patient information service, www.sofomordanek.com.

2002
Diagnostic Imaging Online (November 20, 2002), www.diagnosticimaging.com.

Abstracts

1. Ryken TC, Turner JW, Theriac M, Lim R: Electron microscopic examination of C6 glioma stimulated with glia maturation factor. Proceedings of the 23rd Annual Iowa Electron Microscopy Colloquium, Ames, IA, May 9-10, 1986, pp. 20-21.

2. Ryken TC, Turner JW, Lim R: Morphology of C6 glioma stimulated with glia maturation factor. Abstracts of Medical Student Research Day, University of Iowa, Iowa City, IA, April 4, 1986, p. 10.

3. Ryken TC, Lim R: Induction of cytoskeletal alterations in C6 glioma by glia maturation factor. Abstracts of the 28th Annual National Student Research Forum, Galveston, TX, April 22-24, 1987, p. 8.

4. Ryken TC, Turner JW: Coculture of normal rat astrocytes and C6 rat glioma in vitro. Proceedings of the 25th Annual Iowa Electron Microscopy Colloquium, Ames, IA, May 1988, pp. 23-24

5. Turner JW, Sargent ER, Sandra A, Ryken TC: Scanning electron microscopy and filtration of bile in a liver transplant patient with biliary sepsis. Proceedings of the 26th Annual Iowa Electron Microscopy Colloquium, Ames, IA, May 1989, pp. 24-25.

6. Ryken TC, Turner JW, Sandra A, Lim R: Effects of acidic fibroblast growth factor and transforming growth factor-beta on normal rat astrocytes in vitro. Proceedings of the 27th Annual Iowa Electron Microscopy Colloquium, Ames, IA, May 1990, pp. 19-20.

7. Turner JW, Sandra A, Ryken TC, Barr R: Ultrastructure of endothelium in vitro: analysis of difference in vascular bed, species and culture conditions. Journal of Electron Microscopy Techniques 7(2):146, 1987.

8. Ryken TC, Osenbach RK, Traynelis VC, Lim R: Interaction of acidic fibroblast growth factor and transforming growth factor-beta in fetal rat astrocytes in vitro. Society for Neuroscience Abstracts 17:37, 1991.

9. Ryken TC, Traynelis VC: Mitogenic effects of acidic fibroblast growth factor-beta on bovine and porcine endothelium in vitro. Society for Neuroscience Abstracts 18:955, 1992.

10. Ryken TC, Hitchon PW: Intrathecal baciofen for intractable lower extremity spasticity. Journal of the American Paraplegia Society 16(2):138, 1993.

11. Gerdes JS, Ryken TC, Schelper R, Loftus CM, Traynelis VC: Examination of the blood-cerebrospinal fluid barrier in a canine model. Society for Neuroscience Abstracts 19(1):691, 1993.

12. Sawin PD, Ryken TC, Robertson SC, Traynelis VC: Ultrastructural alterations in 36B10 glioma following irradiation. Society for Neuroscience Abstracts 19(3):1896, 1993.

13. Ryken TC, Traynelis VC: Morphological and ultrastructural alterations in 36B10 glioma treated with cis-parinaric acid. Society for Neuroscience Abstracts 19(3):1897, 1993.

14. Ryken TC, Clausen J, Goel V, Traynelis VC: Comparison of anterior cervical plate screw torque following fatigue with unicortical versus bicortical placement. Journal of the American Paraplegia Society 17(2):110, 1994.

15. Ryken TC, Sawin PD, Runge TC, Traynelis VC: Cytotoxicity of cis-parinaric acid in medulloblastoma. Society for Neuroscience Abstracts 10:835, 1994.

16. Ryken TC, Bush TG, Jat P, Sofroniew M: Grafting of fibroblasts immortalized with thermolabile large T antigen into rat brain. Society for Neuroscience Abstracts 22:766, 1996.

17. Svendsen CN, Rosser AE, Terborg M, Tyres A, Ryken TC: A difference in growth rates between rat and mouse epidermal growth factor responsive CNS precursor cells. Society for Neuroscience Abstracts 22:523, 1996.

18. Ryken TC, Marsh SL, Shetler MM, Rosser AE, Svendsen CN, Sofroniew MV: Characterization of epidermal growth factor generated mouse central nervous system stem cells: potential use in CNS transplant and developmental biology. Journal of Spinal Cord Medicine 20(1):158, 1997.

19. Ryken TC, Watts C, Rosser AE, Svendsen CN, Sofroniew MV: Epidermal growth factor generated central nervous system stem cells: differential culture and characterization. Journal of Neurology, Neurosurgery and Psychiatry, in press.

20. Frankel B, Julien T, Marsh SL, Shetler M, Ryken TC: Fas and fas ligand in malignant glioma: expression and genetic transfer. Society for Neuroscience Abstracts, Vol. 23:2444, 1997.

21. Traynelis VC, Sahu SK, Oberley LW, Buettner GW, Smith D, Ryken TC, Weitather K, Carby C, Martin S: Cytotoxicity of cis-parinaric acid in human glial tumor cells sensitive or resistant to radiation. Society for Neuroscience Abstracts, Vol. 23, 2445, 1997.

22. Frankel B, Longo SL, Julien T, Hahn P, Ryken TC: Fas, fas ligand, tgf-beta2 and bcl2 in the maintenance of immune privilege by gliomas. Society for Neuroscience Abstracts, Vol. 24:2162, 1998.

23. Julien T, Frankel B, Longo SL, Longo J, Kyle M, Hahn P, Ryken TC: The role of bcl2 in human malignant gliomas. Society for Neuroscience Abstracts, Vol. 24:2162, 1998. 2

4. Haller J, Smith K, Ryken TC, Caplan J, Vannier M: Validation of image-guided surgical navigation system. 13th International Congress and Exhibition, Paris, France, June 23-26, 1999, pp. 711-714.

25. Haller J, Tyken TC, Madsen M, Edwards A, Bolinger L, Vannier J: Multi-modality image fusion of image-guided neurosurgery. 13th International Congress and Exhibition, Paris, France, June 23-26, 1999, pp. 681-685.

26. Julien T, Frankel B, Longo SL, Kyle M, Shilletoe E, Ryken TC: Anti-sense mediated inhibition of the bcl2 gene induces apoptosis in human malignant glioma. Society for Neuroscience Abstracts, Vol. 25:2083, 1999.

27. Taggard D, Haller J, Ryken TC, Vannier M: Comparison of dynamic reference frames for image-guided neurosurgery. Society for Neuroscience Abstracts, Vol 25:2084, 1999.

28. Lennarson P, Frankel B, Julien T, Sahu S, Ryken TC: Fas ligand mediated toxicity in human malignant glioma. Society for Neuroscience Abstracts, Vol 25: 2086, 1999.

29. Frankel B, Longo S, Kyle M, Canute GW, Ryken TC: Fas upregulation results in increased survival of rats with intracranial malignant glioma. Society for Neuroscience Abstracts, Vol. 25:2086, 1999.

30. Lennarson PJ, Frankel B, Julien T, Ryken TC: Fas ligand induced cytotoxicity in human malignant glioma. NeuroOncology 2(4):262, Octoboer 2000.

31. Julien T, Frankel B, Longo S, Kyle M, Shilletoe E, Ryken TC: Anti-sense mediated inhibition of the bcl2 gene induces apoptosis in human malignant glioma. Journal of NeuroOncology 45:259, 2000.

32. Julien T, Frank B, Longo S, Kyle M, Shilletoe E, Ryken TC: Adenoviral-mediated anti-bcl2 hammerhead ribozyme induces apoptosis in human malignant glioma. Journal of NeuroOncology 46(3):290, 2000.

33. Frankel B, Longo S, Kyle M, Canute GW, Ryken TC: Fas upregulation results in increased survival of rats with intracranial malignant glioma. NeuroOncology 2(4):262, October 2000.

34. Barua M, Sibenaller Z, Ryken TC: Genetic transciption profiles in glial ontogeny and transformation. NeuroOncology 2(4):262, October 2000.

35. Barua M, Wetjen N, Sibenaller Z, Street W, Lee K, Ryken TC: Image analysis and automatic cell segmentation of malignant glial cells. NeuroOncology 2(4):262, October 2000.

36. Barua M, Sibenaller Z, Ryken TC: Genetic expression profiles in glial ontogeny. Society for Neuroscience Abstracts Volume 26, 2000.

37. Sibenaller, Z.A., Barua M, Ryken T.C.: Comparative Analyses of Rat Tumor Cell Lines to Rat Astrocytes and Rat Stem Cells. Neuro-Oncology, 3(4) 172, November 2001.

38. Barua M, Haller J, Ryken T.C.: Combined Image-Guided Surgical Navigation and Ultrasound Images for Cranial Surgeries. Neuro-Oncology 3(4) 296, November 2001.

39 Sibenaller ZA, Barua M, Ryken TC. CDNA Array Analyses of Rat Tumor Cell Lines to Rat Stem Cells and Rat Astrocytes. Society for Neuroscience Abstracts, Vol 27, 2001.

40. Haller JW, Ryken TC, Buatti JM, Meeks SL. Automatic segmentation of neuroanatomy for treatment planning. International J Radiation Oncology Biological Physics 51:3 (ASTRO 2002):81-82, 2002.

Reviews

1. Ryken TC, Traynelis VC: Free radicals and lipid peroxidation in the central nervous system. Perspectives in Neurosurgery 5(1):105-126, 1994.

2. Ryken TC, Traynelis VC: Biomechanics of cervical instrumentation. Perspectives in Neurosurgery 6:1-18, 1995.

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