Reginald Q. Knight, MD, MHA's portrait
Reginald Q. Knight, MD, MHA
Orthopaedic Spine Surgeon
Director, Bassett Spine Care Institute
Bassett Healthcare Network
Cooperstown, NY
Dr. Knight is a member of the SpineUniverse Editorial Board.

About Reginald Q. Knight, MD, MHA

Dr. Reginald Knight is a Fellowship trained Board Certified Orthopedic Surgeon. Dr. Knight's extensive experience and patient focus set him apart as an outstanding physician. His practice of spinal surgery has spanned two decades and is not limited by spinal region or patient age.

Furthermore, Dr. Knight is the Director of the Bassett Spine Care Institute and President of the Bassett Healthcare Network Medical Staff.

Dr. Knight earned a Doctorate of Medicine from State University of New York at Upstate Medical Center in New York City. He completed a general surgery internship and orthopedic surgical residency through New York Medical College. A Louis Goldstein Spinal Fellow, Dr. Knight completed advanced training in spinal surgery through the University of Rochester School of Medicine at Strong Memorial Hospital in Rochester, NY.

A recipient of many honors and awards, Dr. Knight received the Outstanding Instructor Award from Creighton University in Omaha, NE. During that time he was Associate Professor and Chairman of the Department of Orthopedics and Rehabilitation. In addition, at Creighton University, Dr. Knight served in other important capacities including Director of the Orthopedic Residency Program and Co-Director of the Biomedical Research Center. The University recognized his many other successes and bestowed additional awards to Dr. Knight.

Taking leadership roles in many professional societies, Dr. Knight is an active member of several prominent organizations that include the American Academy of Orthopedic Surgeons, North American Spine Society, Orthopaedic Research Society, Scoliosis Research Society, and Society for Minimally Invasive Spine Surgery (Founding Member). In addition, Dr. Knight is a Founding Board Member of Tabor 100, an organization of African-American businesspeople committed to developing economic and educational excellence and social equity.

An avid researcher and prolific author, Dr. Knight has presented and published more than 250 exhibits, abstracts, journal articles, and textbook chapters. As a Clinical Investigator, Dr. Knight has been very involved in many multicenter clinical trials.

Publications

1. A Better Ankle Support. Knight RQ, Roberge D. Emergency Medicine, 16:6, March 1984.

2. Intraoperative Somatosensory Evoked Potentials: The Rochester Experience. Knight, Chan, Smith, Devanny, and Jackman, Published in the Proceedings from the 3rd International Symposium, October, 1986.

3. Incomplete Spinal Cord Injury Syndromes Status Post Aortic Arch Repair. Knight, RQ., and Devanny, JR. Spine Volume 12, Number 6, 1987.

4. Oxalosis and Accelerated Degenerative Spinal Stenosis: A Case Report. Knight, Taddonio, Smith, Weseley, and Pecker, Orthopaedics, Vol. 11, Number 6, pp. 955-958, June, 1988.

5. "Modified Microdiscectomy: Indications, Technique and Pitfalls". Knight, RQ. Accepted for Publication in Surgical Rounds for Orthopaedics.

6. "Long-Term Follow Up of Posterior Cervical Spine Fusion in Rheumatoid Arthritis". Knight, Cohen, Chan. Transactions of the Association for Academic Minority Physicians, Volume III, Fall/Winter 1989.

7. "Magnetic Resonance Imaging versus Discography". Knight, RQ. Pain Management Update, March/April 1990, pg. 73-75.

8. Idiopathic Scoliosis with Unusual Stress Fracture of Pedicle Within Solid Fusion: A Case Report" Knight, Chan, Spine, Volume 17:7, 849-851, 1992.

9. Neurofibromatosis: Progressive Kyphosis of the Cervical Spine with Anterior Cord Syndrome. A Case Report and Literature Review. Knight, Hieb, Journal of Spinal Disorders, Volume 5:4, 1992.

10. Far Lateral Disc Herniation. Knight, Virginia Mason Clinic Bulletin, Fall 1992, Vol. 46: 66-68.

11. Influence of Pedicle Fixation on Post-Operative Pain. Knight, Chan, Devanny, DiMaio, Journal of Spinal Disorders, Volume 6:2, 141-145, 1993.

12. Lumbar Spine Fusion. Knight, Virginia Mason Clinic Bulletin, Vol. 47: 1-12, Spring 1993.

13. Neurologic Sequelae in Cervical Spine Facet Injuries: The Role of Canal Diameter. Lintner, Knight, Cullen, Spine, Vol. 18, No 6, 725-729, 1993.

14. Complimentary Angles: A Simplification of Sagittal Plane Rotational Assessment in Cervical Instability. Knight, Spine, Vol. 18, No 6, 755-758, 1993.

15. Comparison of Operative versus Non-Operative Treatment of Lumbar Burst Fractures. Knight, Stornelli, Chan, Devanny, Jackman, Clinical Orthopaedics and Related Research, No 293, 112-121, August 1993.

16. Physician Profile: Fact or Fiction. Knight, Wu, McGuckin, Journal of Spinal Disorders, Vol. 9, No 6, pp. 509-517, 1996.

17. Laparaoscopic anterior discectomy and interbody fusion of the lumbosacral spine. Koo, Thirlby, Knight The Official Journal of the Society of Endoscopic & Laparoscopic Surgeons of Asia (ELSA), Vol. 2, No. 1, 5-7, September, 1996.

18. Modified Microdiscectomy as a Day Surgery Procedure. Hom, Knight, McGuckin, Meserve. Virginia Mason Medical Center Bulletin, 50:67-75, Fall 1996.

19. Avascular Necrosis of Lumbar Vertebra, Literature Review and Case Report. Chou, L., Knight, RQ. Spine, Vol. 22, No 16, xx, 1997.

20. Giant Intrathoracic Schwannoma Presenting with Hemothorax. Salcedo-Wasicek, Knight, Pietro, Low. Virginia Mason Medical Center Bulletin, Fall 1997.

21. Major Spinal Surgery in Septuagenarians. Does it improve Patient Function? Knight, RQ Journal of Spinal Disorders, 1999.

22. Osteofil Allograft Bone Paste, Clinical and Radiographic Follow-Up: Case Study Review. Knight RQ, Cillo YA, White Paper for Regeneration Technologies, Inc. October 1999.

23. Arthroscopic Treatment of Gunshot Wounds to the Shoulder. Tarkin IS, Hatzidakis A, Hoxie SC, Giangara CE, Knight RQ, The Journal of Arthroscopic & Related Surgery. Submitted.

24. The Long Gamma Nail: Outcomes and Complications. Urban JA, Mormino MA, Tarkin I, Swanson S, Kumagi S, Knight RQ, Journal of Orthopaedic Trauma. Submitted.

25. Sagittal Balance. Knight RQ, Jackson R, Stanley E, Lowe TG, Winter RW, White Paper for Scoliosis Research Society Website, September, 2002.

26. Interobserver reliability in the interpretation of diagnostic lumbar MRI and nuclear imaging. DS. Mulconrey, RQ. Knight, JD. Bramble, S Paknikar, PA. Harty, The Spine Journal, March - April; 6 (2) 2006, 177-184.

27. Direct-Lateral Lumbar Interbody Fusion For Degenerative Conditions: Early Complication Profile. RQ. Knight, P. Schwaegler, D. Hanscom, J. Roh, Submitted to Publication The Spine Journal (Fall 2006).

Abstracts:
1. Taddonio, RF., Knight, RQ.: Analysis of Sagittal Curves and Midline Compensation in Idiopathic Scoliosis Treated with Luque Segmental Instrumentation. 20th Annual Meeting of the SRS, San Diego, USA September 17-20, 1985.

2. Taddonio, RF., and Knight, RQ.: Analysis of Sagittal Curves and Midline Compensation in Idiopathic Scoliosis Treated with Luque Segmental Instrumentation. European Spinal Deformities Society First Congress, Rome, Italy April 16-19, 1986.

3.Pedicle Screw Fixation--Effects on Lumbar Lordosis and the Incidence of Aberrant Screw Placement: "Assessment of Early Results". Knight, Chan, Devanny, Jackman, Montgomery, Hieb, SRS/NASS Pedicle Fixation Workshop, Dallas, Texas March 16-17, 1990.

4. Neurofibromatosis: Post Laminectomy Kyphosis of the Cervical Spine with Anterior Cord Syndrome. A Case Report and Literature Review. Knight, Hieb, The Journal of the American Paraplegia Society, April 1991, Vol. 14, # 2, pg. 107.

5. "Comparison of Operative versus Non-Operative Treatment of Lumbar Burst Fractures". Stornelli, Knight, Chan, Devanny, Jackman, The Journal of the American Paraplegia Society, April 1991, Vol. 14, # 2, pg. 68.

6. Neurologic Sequelae in Cervical Spine Facet Injuries: "The Role of Canal Diameter ". Lintner, Knight, Cullen , The Journal of the American Paraplegia Society, April 1991, Vol. 14, # 2, pg. 108.

7. Laminoplasty for Treatment of Multilevel Cervical Stenosis. Hieb, Knight, The Journal of the American Paraplegia Society, April 1991, Vol. 14, # 2, pg. 10.

8. Bone SPECT Utility in Patients referred for Suspected Mechanical Spine Pain. Eisenberg, Knight, Gass, Coates, Lee, Journal of Nuclear Medicine, May 1994.

9. Outcome Assessment in Elective Spine Surgery. Knight, McGuckin, N M A 100th Anniversary Abstracts of Scientific Papers, pp. 34, 1995.

10. Single Stage Posterior Fusion for Degenerative Scoliosis: Outcome Assessment. Knight, McGuckin N M A 100th Anniversary Abstracts of Scientific Papers, pp. 35, 1995.

11. Bone Healing is Impaired in Ethanol-Fed Rats. Chakkalakal, Novak, Fritz, Mollner, McVicker, Pileri, Garvin, Knight, 23rd Annual Meeting of the Research Society of Alcoholism, Alcohol Clin Exp Res 2000; 24(5) Suppl: 132A.

12. Screening of Osteoconductive Biomaterials Proposed as Vehicles for Growth Factor Application in Bone Repair. Chakkalakal, Strates, Gravin, Novak, Fritz, Mollner, Knight, 110th Annual Meeting of the Nebraska Academy of Sciences, Proceedings of, p. 58; April 2000.

13. Osteiopenia in Rates Due to Ethanol Consumption and Reduced Food Intake. Chakkalakal, Novak, Fritz, Mollner, McVicker, Pileri, Garvin, Knight, Donohue, 47th Annual Meeting of the Orthopaedic Research Society, p. 135; February 2001.

14. Medullary Osteogenesis Following Marrow Injury. Bechtold, Knight, Novak, Mollner, Fritz, Chakkalakal, 111th Annual Meeting of the Nebraska Academy of Sciences, Proceedings of, p.41; April 2001.

15. Response of Rat Femur to an Intramedullary Titanium Wire Implant. Tran, Knight, Novak, Mollner, Fritz, Chakkalakal, 111th Annual Meeting of the Nebraska Academy of Sciences, Proceedings of, p.42; April 2001.

16. Role of Osteoconduction in the Intramuscular Bioassay for Osteoinductive Activity. Meisterling, Knight, Novak, Mollner, Fritz, Chakkalakal, 111th Annual Meeting of the Nebraska Academy of Sciences, Proceedings of, p.42; April 2001.

17. Treatment of Bone Defects with Combination of BMP-2 and PDGF-AA. Chakkalakal, Strates, Novak, Fritz, Mollner, Knight, 111th Annual Meeting of the Nebraska Academy of Sciences, Proceedings of, p.43; April 2001.

18. Effects of Alcohol on Cell Function in a Bone Repair Model. Chakkalakal, Mollner, Langan, Fritz, Novak, Knight, Donohue, White, Wilkin, 112th Annual Meeting of the Nebraska Academy of Sciences, Proceedings of, p.48; April 2002.

19. Acceleration of Bone Formation in Injured Marrow Cavity by TGF-Beta. Kakarlapudi, Gritz, Mollner, Langan, Novak, Cullen, Knight, Chakkalakal, 112th Annual Meeting of the Nebraska Academy of Sciences, Proceedings of, p.47-48; April 2002.

20. Methods to increase Bone Ingrowth in Noncemented Hip Replacement in the Elderly. Chakkalakal, Redepenning , Garvin, Novak, Fritz, Mollner, Knight, 112th Annual Meeting of the Nebraska Academy of Sciences, Proceedings of, p.47; April 2002.

21. Validity of the Intramuscular Bioassay for Osteoinductive Activity. Meisterling, Strates, Knight, Novak, Mollner, Gritz, Chakkalakal, 48th Annual Meeting of the Orthopaedic Research Society, February 2002.

22. Canine Model for Noncemented Hip Reconstruction in the Elderly. Chakkalakal, Redepenning, Garvin, Novak, Fritz, Mollner, Knight, 48th Annual Meeting of the Orthopaedic Research Society, February 2002.

23. The Relationship between Vascular Endothelial Growth Factor 164 Isoform mRNA Expression and Bone Healing. Patel P, Langan A, Johnson M, Clemens D, Mollner T, Fritz E, Novak J, Knight R, Chakkalakal D. 49th Annual Meeting of ORS, New Orleans, Louisiana, February 2003.

24. Transforming Growth Factor-Beta 1 Accelerates New Bone Formation after Medullary Reaming. Kakarlapudi R, Fritz E, Mollner T, Novak J, Langan A, Knight R, Chakkalakal D. 49th Annual Meeting of ORS, New Orleans, Louisiana, February 2003.

25. Methods to improve Noncemented Fixation of Hip Prosthesis in the Elderly. Chakkalakal D, Redepenning J, Garvin K, Novak J, Fritz E, Mollner T, Knight R. 49th Annual Meeting of ORS, New Orleans, Louisiana, February 2003.

26. Effects of Alcohol on Cell Function in a Bone Repair Model. Chakkalakal D, Mollner T, Langan A, Fritz E, Novak J, Knight R, Hoarah J, White R, Witkin D, Donohue T Jr., 49th Annual Meeting of ORS, New Orleans, Louisiana, February 2003.

27. The Relationship between Vascular Endothelial Growth Factor 164 Isoform mRNA Expression and Bone Healing. Patel P, Langan A, Johnson M, Clemens D, Mollner T, Fritz E, Novak J, Knight R, Chakkalakal D. National Student Research Forum, Galveston, Texas, April 2003.

28. Stimulation of meduallary osteogenesis by TGF-1 and IGF-1. Babbel D, Fritz ED, Mollner TJ, Novak JR, Langan A, Knight RQ, Chakkalakal D. National Student Research Forum, Galveston, Texas, April 2003.

29. COX-2 Inhibition Delays Formation of Mature Bone by Osteoblasts. Macalena JA, Knight RQ, Mollner TJ, Langan A, Gritz ED, Novak JR, Adickes ED, Chakkalakal D. National Student Research Forum, Galveston, Texas, April 2003.

Articles Written by Reginald Q. Knight, MD, MHA

Common and Uncommon Causes of Back Pain

Muscle spasms may be the most common cause of back pain, but there are other common causes patients with back pain need to know about. Plus, two uncommon spinal disorder are explained.

References: Direct Lateral Transpsoas Approach

The list of References to Dr. Reginald Knight's article about the minimally invasive lumbar interbody fusion procedure, DLIF or Direct Lateral Transpsoas Approach.

Discussion: Direct Lateral Transpsoas Approach

Direct lateral transpsoas lumbar interbody fusion may prove to be an important improvement in our methods of handling degenerative conditions affecting the lumbar spine.

Direct Lateral Transpsoas Lumbar Approach

A less invasive direct lateral transpsoas approach to the lumbar spine has proved to be an effective method of managing patients requiring interbody fusion of the mid-lumbar spine.

Results: Direct Lateral Transpsoas Approach

DLIF complications that altered the discharge plan or patient function, occured in 10 out of 38 patients. Two tables detail these complications.

Procedure Description: Direct Lateral Transpsoas Lumbar Interbody Fusion

Doctor Reginald Knight describes the direct lateral transpsoas lumbar interbody fusion procedure. Included are several intraoperative images.

Open Anterior Lumbar Interbody Fusion (ALIF) - An Introduction

If a patient with serious, long-term low back pain is not helped by nonoperative programs, a surgical procedure such as anterior lumbar interbody fusion might be considered.

Recent blog posts from Reginald Q. Knight, MD, MHA

January 19, 2012

Will I Eventually Need Surgery for Degenerative Disc Disease?

I'm 60, and I just found out that I have degenerative disc disease (DDD). Since it's a degenerative condition, I assume it'll just get worse as I get older. What's the likelihood of me needing surgery for DDD?

December 15, 2011

Should I Have Surgery for Lumbar Spondylosis?

I’ve had lumbar spondylosis for the last 4 years and have found zero relief with physical therapy, exercise, and medications. The pain is consistently about an 8 out of 10. I’ve just started to research surgery for spondylosis. Could surgery help me?

January 12, 2011

Pain after Spine Surgery

"I had posterior lumbar interbody fusion surgery for a herniated disc at L4-L5 about a year and a half ago, but I'm still in horrible pain. I'm only 45, so I'm very worried that I'll have to live with this pain for the rest of my life. Is this common? Will I need another surgery?"

More from Dr. Knight's blog "Dr. Knight's Notes"

Case Studies Presented by Reginald Q. Knight, MD, MHA

Degenerative Scoliosis with Left L3 Radiculopathy

Patient Presents with Mechanical Low Back Pain and Neurogenic Claudication
Presented by: R. Knight MD, MHA
The patient is a high-functioning 80-year-old female who presents with mechanical low back pain, left L3 radiculopathy, and neurogenic claudication. How should she be treated? When do you recommend spine surgery?

Cervical Spondylotic Myelopathy in an Amateur Golfer

Presented by: R. Knight MD, MHA
The patient is a 63-year-old male presenting with complaints of upper extremity paresthesia, loss of dexterity and irregular gait. He denies bowel or bladder irregularity.

Low Back Pain Two Years Post Recurrent Disc Excision

Presented by: R. Knight MD, MHA

Two years ago, the patient underwent L5-S1 recurrent disc excision that provided relief of radicular pain. She now presents with worsening low back pain.

New Onset of Low Back Pain

Presented by: R. Knight MD, MHA

The patient is a truck driver who presents with a new onset of low back pain two years after spinal fusion.

Degenerative Disc Disease: Lumbar Interbody Fusion or Artificial Disc?

Presented by: R. Knight MD, MHA

The patient rates her pain as 7/10 and exhibits decreased active lumbar range of motion in all planes. She has not been responsive to epidural and facet injections.

Adolescent Disc Herniation: Conservative or surgical treatment?

Presented by: R. Knight MD, MHA

A 17-year-old male soccer player, who landed awkwardly during a game, presented with a 6-month history of increasing low back and buttock pain. Presented is the patient's history, physical exam, diag

Financial Disclosures

SpineUniverse, a Vertical Health, LLC website, is committed to ensuring that the medical information it presents is accurate, balanced, objective, and trustworthy. 

To help achieve this goal, SpineUniverse requires all authors, editors, and reviewers to disclose any financial relationships or affiliations they have with companies whose products or services may be mentioned in the content they author, edit, or review.

The intent of this policy is to identify any perceived, potential, or real conflicts of interest so that readers can make their own judgments about the value of information being presented.

Author's Statement

I, or an immediate family member, have a financial interest(s) or affiliation(s) with the following commercial companies whose products and / or services may be mentioned in the materials I have authored, edited or reviewed for presentation on Vertical Health, LLC’s websites.

Disclosed Relationships

Grants/Research Support
Archus Orthopedics, Spinal Motion
Consultant
Medtronic, Stryker
Other Financial or Material Support
Royalty: Stryker
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